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【天工论坛第22期】Challenges and Opportunities for Natural Products by Synthetic Biology
  發布時間:2018-10-23    供稿部門:

  报 告 人:沈奔 美國斯克裏普斯研究所化學系教授、分子治療系兼職教授,化學系主任 

  報告題目Challenges and Opportunities for Natural Products by Synthetic Biology 

  報告時間1029日(周一) 9:30 

  報告地點:天津工業生物所B301階梯教室 

  報告摘要:Natural products are made from simple building blocks, the structural diversity found in natural products is the result of Nature's intrinsic use of combinatorial biosynthesis, and progress in connecting natural products to the genes that encode their biosynthesis has fundamentally changed the landscape of natural products research. Advances in microbial genomics and synthetic biology have made it possible to produce designer natural products by de novo metabolic pathway construction and rational pathway engineering. Current strategies are mainly based on the collective knowledge of genetics, microbiology, evolution, enzymology,and structural biology that governs the natural product biosynthetic machinery. While successful, they are limited by what information is gleaned from the above disciplines and how that information can be applied to construct the designer pathways. Nature has used evolution over billions of years to become an expert in combinatorial biosynthesis, and we have only begun to tap into this knowledge. Selected examples from our current studies will be presented to highlight the opportunities in accessing natural products and expanding natural product structural diversity by exploring the vast combinatorial biosynthesis repertoire found in Nature. 

  報告人簡介:沈奔,美國斯克裏普斯研究所化學系教授、分子治療系兼職教授,化學系主任。曾担任美国威斯康星大学麦迪逊分校药学院讲席教授。沈奔教授致力于微生物來源天然産物的生物合成機制及其調控的研究,綜合應用有機化學、生物化學、天然産物化學和分子生物學技術,對微生物來源天然産物的化學結構、生物合成酶及基因進行闡述,並以此作爲發現和開發新藥的新方法,在ScienceNatureCellPNASJACSJBCNature Chemical Biology等國際一流學術期刊上發表了約300篇論文。沈奔教授是《J. Ind. Microbiol. Biotech.》主編、《J. Nat. Prod.》、《J. Antibio.》、《Mol. BioSyst. 》、《Current Bioactive Compounds》等國際主流期刊的編委或顧問委員,同時還擔任了多家著名醫藥公司和生物技術公司的技術顧問。曾獲得多種科學獎項及榮譽:美國工業微生物學與生物技術學會Charles Thom(2018);美國微生物學學會PROMEGA生物技术研究獎(2015);美國微生物学科學研究院Fellow (2011);美國科學促進會Fellow (2011);美國生藥學會Jack L. Beal(2002);美國Searle學者計劃(1997-2000);美國国家自然科学基金会CAREER(1998-2003);美國国立卫生研究院Independent Scientist (2001-2006);美國生藥學會Matt Suffness(2000);美國国立卫生研究院FIRST(1996-2001) 

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